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FIGURE 5 3.6 FOXO4-DRI promotes apoptosis in senescent cells As established in prior research, FOXO4-DRI competitively binds to p53 with high affinity, thereby disrupting its nuclear interaction with FOXO4
In its briefing document for the meeting, the agency proposed that every one of the seven peptides on the two-day agenda be kept off the list
Every peptide in our catalog, including research compounds targeting metabolic pathways, undergoes third-party verification before release
10.1007/s10787-017-0330-7 42 MasnecS.KokotA.ZlatarM.KalauzM.KunjkoK.RadicB.et al (2015)
PDB codes of previously published structures used in this study are 4HJE (human p53 DBD), 3L2C (human FOXO4 FH domain bound to DNA) and 1E17 (human FOXO4 FH domain)
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